Fixed-term of 3 years | Full-time with 38,5 hours | Salary level according to TV-L E13 | The Institute for Experimental Pathology
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in the Institute for Experimental Pathology based at the Center for Inflammation Research at the University of Münster – ideally with you on board!
PROJECT TITLE:
1. Investigating the role of Immature Granulocytes in Atherosclerosis
THE INSTITUTE AND PROJECT:
The Institute for Experimental Pathology is led by Oliver Soehnlein. His work focuses on the importance of neutrophils in acute and chronic inflammation with specific focus on atherosclerosis and its complications such as myocardial infarction and neointimal hyperplasia (Soehnlein et al., Sci Transl Med, 2011; Ferraro et al., JACC, 2019; Silvestre-Roig et al., Nature, 2019; Schumski et al., Circulation, 2021). Central to the group's mechanistic understanding of how neutrophils promote chronic, sterile inflammation is its interplay with antigen presenting cells, predominantly macrophages (Soehnlein & Lindbom, Nat Rev Immunol, 2010; Soehnlein et al., Nat Rev Immunol, 2017; Soehnlein & Libby, Nat Rev Drug Discov, 2021). It is a key feature of the group's work to unveil thus far unknown mechanistic details which are then translated towards innovative preclinical intervention strategies (Alard et al., Sci Transl Med, 2015; Silvestre-Roig et al., Nature, 2019), some of which have been patented. Our group is highly interdisciplinary, international, and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, (spatial) single cell omics and bioinformatics. The project is embedded in national and international consortia on cardiovascular inflammation and funded by Novo Nordisk, hence enabling a strong translational link.
More information here: ; ;
RESPONSIBILITIES:
2. Design and conduct experiments utilizing state-of-the-art approaches such as: Flow cytometric analysis of immune cell populations from murine tissues using full spectrum flow cytometry Immunohistological staining and imaging of tissue sections using multiplexed immunohistochemistry Biochemical assays for cytokines and other inflammatory mediators
3. Collaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of atherosclerosis pathophysiology
4. Analyze data, interpret results, and present conclusions through high-quality publications, presentations, and reports
5. Contribute to manuscript preparation, grant writing, and peer review activities
6. Participate actively in departmental seminars, workshops, and conferences
REQUIREMENTS:
7. PhD degree in Biological Sciences, Biomedical Engineering, or related fields
8. Strong background in molecular biology, cellular immunology, and/or vascular biology
9. Expertise in one or more of the following areas: Murine genetics and breeding strategies Flow cytometry-based phenotyping and sorting Immunofluorescence microscopy and histopathological evaluation Statistical programming languages like R or Python
10. Excellent communication skills in English; proficiency in German desirable but not required
11. Ability to work independently while contributing effectively to collaborative projects
12. Willingness to participate in ongoing training programs to enhance expertise and stay up-to-date with latest methodologies
WE OFFER:
13. Competitive salary according to TV-L E13 scale, full time, initially limited to three years
14. Comprehensive benefits package including health insurance, pension plan, and family support services
15. Access to world-class infrastructure, equipment, and resources
16. Opportunities for professional growth, networking, and international collaboration
17. Supportive environment fostering creativity, innovation, and interdisciplinary exchange
For inquiries, please contact: Oliver Soehnlein, T 0251 83 53001
Apply now via our career portal until 12.03.2025 including:
18. Cover letter highlighting relevant experience, interests, and career goals (max. 2 pages)
19. Curriculum Vitae with publication list and academic record
20. Contact details for two referees familiar with your scientific achievements