The Medical Faculty of the Martin Luther University Halle-Wittenberg invites applications for seven positions within the mikroPank research consortium. This interdisciplinary initiative is dedicated to developing preclinical, patient-specific models to advance personalized treatments for pancreatic cancer patients. Research Assistant / PhD Student (m-f-d) (E 13, 65 %) We are hiring: Three PhD students (E13, 65%), reference number: 7-242/24-D All positions are available immediately and are temporary, until December 31, 2027. About the mikroPank consortium: The consortium is deticated to creating 3D tumor models from primary, patient-derived tumor cells and components of the tumor microenvironment, such as fibroblasts, adipocytes, and immune cells. These models replicate the patient-s tumor in-vitro to study mechanisms of drug resistance using advanced technologies, including single-cell RNA sequencing (scRNA-seq) and CRISPR-based genome editing. By integrating natural sciences and clinical expertise, the consortium aims to advance research towards innovative, personalized therapies for pancreatic cancer patients. Work Tasks: Cultivation of pancreatic tumor organoids and cells of the tumor microenvironment Single-cell RNA sequencing (scRNA-seq) Genetic manipulation of cells using CRISPR Independent project management Participation in national and international collaborations Opportunity for own scientific qualification Completed scientific university degree in the field of life sciences (Master) Experience with cell culture techniques, ideally experience in the culture of pan-creatic tumor organoids Knowledge of lentiviral transduction Practical experience with single-cell RNA sequencing (scRNA-seq) Programming experience in R is an advantage Scientific processing, presentation and publication of achieved results Very good written and spoken English language skills Analytical and problem-oriented thinking Structured and thorough way of working Ability to work in a team Collaborative research environment with communication in English Access to state-of-the-art equipment, facilities and resources Opportunities for national and international collaborations and conference visits