The Georg-Speyer-Haus in Frankfurt am Main, Institute for Tumor Biology and Experimental Therapy, is an academic non-profit research institute supported by the Federal Ministry of Health and the Ministry for Sciences and Arts of the State of Hessen. The institute is dedicated to basic and translational cancer research in the context of the tumor microenvironment and closely cooperates with the Goethe University Frankfurt and the Frankfurt University Hospital. It provides access to a broad variety of core facilities and an excellent scientific environment. We are seeking a Doctoral Researcher in Computational Cancer Biology (m/f/d) to join the lab of Dr. Michael Tyler at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy, applying data Integration approaches to understand the changes in cellular heterogeneity during cancer progression. Project description Our lab aims to characterise the changes in cell states and interactions between healthy tissue, primary tumours and advanced cancer stages. Our work is centred around the curation and integration of many published genomic datasets, with a focus on single-cell RNA-seq (scRNAseq) and spatial transcriptomics data. By conducting large-scale comparisons of transcriptomic and spatial profiles across many patients, cancer types and disease stages, we aim to uncover robust signatures of cancer progression that reveal general principles of tumour development and suggest new therapeutic opportunities. This work involves analysis of large datasets with statistical computing tools, using a high-performance computing cluster. Key tasks include curating datasets; developing computational methods for detection and comparison of cell states and interactions; and interpreting results to yield clinically relevant insights. Specific challenges include efficient handling of large volumes of data, and controlling for technical artefacts while preserving biological effects. Read more about the research of Michael Tyler on our website. Requirements * Masters degree in life sciences or a numerical discipline. * A strong interest in cancer research and computational biology. * High motivation, curiosity, proactivity and creativity. * Willingness to engage in a collaborative environment. * Proficiency in English. We offer * Excellent mentorship and development of a scientific profile. * An outstanding international cancer research environment. * A collaborative and friendly atmosphere. * Participation in further training programs. * A salary in accordance with the agreement for public service of the state of Hessen (E13, 65 %), including social benefits, available for 3 years with the option for extension. Interested? Applications should be submitted electronically to as a single PDF containing a cover letter, CV, publication list, the names and contact details of two referees, and degree certificates. For further information, please contact Dr. Michael Tyler ( ). Our international working environment promotes equal opportunities for all staff regardless of gender, age, cultural background, nationality or impairments under criteria of scientific excellence. Applications from women are explicitly welcome. Disabled individuals will be preferred in case of equal qualification. For Information about the Georg-Speyer-Haus please visit our homepage. Georg-Speyer-Haus Paul-Ehrlich-Str. 42-44 | Frankfurt/Main