With cutting-edge research in the fields of ENERGY, HEALTH and MATTER, around 1,500 employees from more than 70 nations at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) are committed to mastering the great challenges facing society today.
At the Institute of Radiopharmaceutical Cancer Research scientists (f/m/d) from the fields of physics, chemistry, biology, pharmacy, immunology, medicine and IT develop innovative radiopharmaceuticals and novel tools for functional characterization, improved imaging and personalized treatment of tumors.
The Department of Radioimmunology is looking for a PhD Student (f/m/d) Preclinical development and validation of adapter CAR T cell systems for targeting and modulation of the immunosuppressive microenvironment of solid tumors. Recruitment is subject to final approval by the project sponsor.
Your tasks
* Generation and characterization of adapter CAR-expressing human T cells
* Design, generation and characterization of targeting molecules for redirection of adapter CAR T cells to tumor cells
* Testing the functionality and efficiency of the novel targeting molecules and adapter CAR T cell systems using 2D and 3D spheroid models in vitro and/or in mouse models
Your profile
* Completed university studies (Master/Diploma) in the field of Biology, Biotechnology, (Bio-) Chemistry or equivalent (e.g. must have completed their medical studies) or related field
* Solid knowledge of immunology and/or protein biochemistry
* Good skills/experience in molecular biology, protein biochemistry, generation of recombinant proteins, working with cell cultures, flow cytometry and mouse models
* Be fascinated by scientific research and innovation, be motivated, enthusiastic and eager to learn, be able to work methodically and accurately, be able to work independently yet also being a team player, have a creative mind and strong problem-solving skills and have a good writing and oral expression
* Speak and write fluently in English
Our offer
* A vibrant research community in an open, diverse and international work environment
* Scientific excellence and extensive professional networking opportunities
* A structured PhD program with a comprehensive range of continuing education and networking opportunities - more information about the PhD program at the HZDR can be found here
* Salary and social benefits in accordance with the collective agreement for the public sector (TVöD-Bund) including 30 days of paid holiday leave, company pension scheme (VBL)
* We support a good work-life balance with the possibility of part-time employment, mobile working and flexible working hours
* Numerous company health management offerings
* Employee discounts with well-known providers via the platform Corporate Benefits
* An employer subsidy for the "Deutschland-Ticket Jobticket"
We look forward to receiving your application documents (including cover letter, CV, diplomas/transcripts, etc.), which you can submit via our online-application-system.
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