The Department of Dermatology, University Hospital Tübingen, in the working group of Prof. Dr. rer. nat. Birgit Schittek - Molecular Mechanisms of Melanoma Progression and Therapy Resistance -, the position of a PhD student (E13 65%) or a postdoc (E13 100%) is to be filled from 1.4.2025 on or later. The position is initially limited to 3 years. The scientific focus is a DFG funded project to investigate the role of CDKN1A/p21-dependent DNA damage response pathways in increasing the efficiency of targeted therapy in melanoma. The tasks of the research associate include the implementation of a wide variety of methods: molecular biology methods (qRT-PCR, RNA isolation, cloning, reporter gene analysis), biochemical methods (e.g. SDS-PAGE, Western blot, chromatography, proteomics), immunological methods (immunofluorescence, immunoprecipitation, ELISA, FACS) and cell biological methods (e.g. cell culture, 3D skin model, transfections, proliferation tests, apoptosis assays), mouse experiments using a melanoma tumor model. Applicants should be reliable and able to work in a team and have good practical experience in diverse cell biological, immunological and infectious research skills and with the methods mentioned above. Experience in cell culture and animal experiments is an advantage. In addition, we expect the results to be documented on the computer with the Windows programs Word, Excel, Power Point, GraphPad Prism.Applicants should already stay in a European country and should have a residence permit to work in Germany for the next three years.