Job Description The job that makes possibilities real in patients' lives. And yours. The job that helps you get ahead in life. Moving mountains together. Welcome to AbbVie As part of an international company with 48,000 employees worldwide and around 3,000 employees in Germany, you will have the opportunity of addressing some of tomorrows unmet medical needs in close collaboration with your colleagues. Are you passionate about improving global health care? Do you want to contribute to improving patients' quality of life through your expertise? In a challenging work environment that offers opportunities of developing and increasing your own skills? Youve come to the right place Moving mountains together – as PBPK Modeler (all genders) (permanent / full-time) The Quantitative, Translational and ADME Sciences (QTAS) team at AbbVie, Inc. is seeking a scientist in the Germany who can perform a role as Physiologically-Based Pharmacokinetics (PBPK) modeler to provide small molecule project support across multiple therapeutic areas. The successful candidate will be responsible for conducting static and mechanistic PBPK, human PK, and drug-drug interactions (DDI) projections using in vitro and in vivo ADME/PK data to support Discovery and Development project teams, enabling compound progression from discovery to early stages of clinical development. The position will require close collaboration with lab functions within QTAS, Discovery project teams and other R&D stakeholders in order to develop and execute QTAS strategies necessary to select and facilitate the advancement of optimized candidate molecules. In this exciting and dynamic role you will also be expected to evaluate new technologies and approaches to support the mechanistic and translational understanding of drug disposition and drug-drug interactions. The ideal candidate will have strong background and hands-on experiences in PBPK modeling using a commercial software (e.g. Simcyp). Responsibilities Predict human PK and DDI profiles of small molecule drug candidates utilizing pre-clinical in vitro and in vivo ADME/PK data and static and mechanistic modeling tools Support project teams across multiple therapeutic areas and interpret results through close partnership with QTAS representatives Effectively communicate human PK/DDI prediction and PBPK modeling, QTAS strategy and knowledge to project teams, functional leaders, and other key stakeholders to ensure alignment and influence decisions Demonstrate thorough understanding of drug metabolism, pharmacokinetics and bioanalysis (DMPK-BA) necessary for the characterization of small molecule drug candidates to support regulatory submissions Stay current with latest developments in the field of human PK and DDI predictions including empirical (e.g. allomeric scaling) and more mechanistic models (e.g. PBPK)