The Department of Dermatology, University Hospital Tübingen, in the working group of Prof. Dr. rer. nat. Birgit Schittek - Molecular Mechanisms of Melanoma Progression and Therapy Resistance -, the position of a PhD student (E13 65%) is to be filled from 1.2.2025 on.
The scientific focus of the project is the analysis of the role of the guanine exchange modulators Girdin and Daple in melanoma progression and therapy resistance. There is a close cooperation with the other members of the research training group. The tasks of the PhD student include the implementation of a wide variety of methods: molecular biology methods (qRT-PCR, RNA isolation, cloning, reporter gene analysis), biochemical methods (e.g. SDS-PAGE, Western blot, chromatography), immunological methods (immunofluorescence, immunoprecipitation, ELISA, FACS) and cell biological methods (e.g. cell culture, 3D skin model, transfections, proliferation tests, apoptosis assays), mouse experiments using a melanoma tumor model. Applicants should have a master in the field of natural sciences or molecular medicine, be reliable and able to work in a team and have good practical experience in molecular, cell biological and biochemical research skills and with the methods mentioned above. Experience in cell culture and animal experiments is an advantage. In addition, we expect the results to be documented on the computer with the Windows programs Word, Excel, Power Point, GraphPad Prism. The position is initially limited until October 2027 with the option to extend. The PhD student will be member of the DFG- funded research training group “Non-canonical G protein signaling pathways”. For further details see https://www.rtg2816.com/news.