The Fraunhofer-Gesellschaft currently operates 76 institutes and research units throughout Germany and is a leading applied research organization. Around 32 000 employees work with an annual research budget of 3.4 billion euros.
The Fraunhofer branch Translational Neuroinflammation and Automated Microscopy TNM in Göttingen is part of the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP. The Research group »Translational Neuroinflammation« focuses on understanding pathological and immunological mechanisms in the development and progression of demyelinating diseases of the central nervous system.
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. For relapsing-remitting MS, huge progress has been made in the development of various disease-modifying therapies such as anti-CD20 antibodies, which effectively reduce the number and the severity of new relapses as well as MRI activity.
Currently, our research group invites applications for a PhD student position in the field of cell biology and immunology. The aim of this study is to compare various immunomodulating therapies, utilizing in vitro and in vivo experiments. We will utilize the murine MS model, experimental autoimmune encephalomyelitis, as well as primary cell cultures and human samples. We also aim to better understand the pathogenesis of MS. Therefore, we plan to analyze cell-cell interaction to find candidates for molecular tracing. The main methods of this study will be, among others, flow cytometry, magnetic-activated cell sorting, ELISA, qPCR, bulk RNA-Seq, microscopy, and immunohistology.
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