Job Description
1. Utilize modern sequencing-based molecular biology approaches (RNA-seq, ChIP-seq, HiChIP, Hi-C, PRO-seq, etc.) to test hypothesis and examine epigenetic and gene regulatory mechanisms controlling pancreatic tumor cell identity and therapy response.
2. Bioinformatic analysis and interpretation of data followed by hypothesis testing and generation.
3. Perform multiplex immunofluorescence staining to confirm gene regulatory mechanisms in primary tumor tissue using multispectral imaging with an Akoya PhenoImager.
4. Perform tissue-based preparation of histological samples (FFPE tumor material) for single cell RNA-sequencing using the 10X Genomics technology.
5. Perform advanced cell culture experiments to examine the effects of drug treatment in various translational model systems.
6. Participation in internal or external research collaborations.
7. Documentation of work procedures, data acquisition and analyses
Qualifications
8. Applicants must have completed a Master of Science in a related field (biology, molecular biology, biotechnology or similar)
9. The applicant must have already secured or be able to secure external funding for their position (, doctoral fellowship from DAAD, China Scholarship Council, or similar)
10. Experience with cell culture, transfections, etc.
11. Extensive molecular biology experience (real-time PCR, Western blot, etc.)
12. Strong interest in learning and gaining proficiency in bioinformatic analyses
13. Strong work ethic and high level of self-motivation
14. Independent, goal-oriented and structured way of working and ability to work in a team
15. Confident written and spoken English skills
Additional Information
We offer you:
16. An exciting and international research environment
17. Excellent experience and expertise in modern epigenetic methods
18. Outstanding bioinformatic expertise
19. Extensive modern infrastructure for all methods related to the project
20. Working in a committed team, characterized by mutual appreciation and support
21. Proven track record of successfully supervising more than 20 doctoral students to completion
22. Long track record in gene regulation and cancer research (see )
This position is contingent upon the applicant having attained or attaining an externally funded fellowship for the duration of their project.
Contact:
Prof. Dr. Steven A. Johnsen
Scientific Director
E-Mail:
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