The Heinrich-Heine University hosts more than 35,000 students in the beautiful city of Duesseldorf. You will be located at the Department of Neurology, Medical Faculty and University Clinic Duesseldorf. The research training group (RTG) 2578 "Impact of genotoxins on the differentiation efficacy of murine and human stem and progenitor cells and functional competence of thereof derived differentiated progeny" combines groups from the faculties of natural sciences and medicine (https://www.grk2578.hhu.de/en). The research group \"thiology\" is interested in the identification of thiol redox switches regulating physiological and pathological processes. For more information about our research and our activities please see www.thiology.de.
In the project embedded in the RTG2578 (/project 1b) you will investigate the role of hydrogen peroxide in the nucleus. You will discover the impact of this reactive oxygen species on DNA damage and repair, oxidation of proteins and lipids in the nucleus and how these modifcations affect differentiation of neural stem/progenitor cells.
You will plan and perform experiments using in vivo (mice, zebrafish), ex vivo (organotypic slice cultures), and in vitro (cell lines) models and different techniques in the fields of cell biology, biochemistry, and molecular biology.
The results you will present in the RTG seminars on a regular basis, receive feedback and suggestions for further steps in the project and promote the scientific exchange between the projects as well as at international congresses. You are welcome to apply for the position when
- you have a master degree in biology, biochemistry, or related fields
- you have experience with the model organism mouse, cell culture work, and wet lab techniques
- you are motivated to work on a scientific project (which includes sometimes weekends and evenings)
- you are able to use the english language
- you are a teamplayer Your salary will be according to TVL-E13 65% for three years.
In addition to the daily practical laboratory work, the PhD students participate in a extensive training program. This includes lectures about the basics of the RTG topics by the GRK project leaders and invited national and international guest speakers.
Special importance is attached to the further training of the students in areas of modern and future-oriented toxicology, in that they take part in the further qualifying training of the doctoral students to become European Registered Toxicologist.
Furthermore, the students of the RTG 2578 are members of the Interdisciplinary Graduate and Research Academy Düsseldorf (iGRAD) and, depending on their interests, attend workshops and advanced training courses to acquire further key qualifications.
Our research group is part of the neurology research laboratory and offers several national and international collaborations.